Pancreatic Beta-cell function and degree of Insulin resistance among newly detected type 2 diabetics and their correlation with anthropometric, glucose, and lipid parameters: An Observational cross-sectional study

Background: Insulin resistance is a major cause for developing type 2 diabetes. However, simultaneously pancreatic beta-cell dysfunction must coexist in clinical occurrence of diabetes (T2D). Hence, knowledge regarding residual function and degree insulin required while treating diabetic patients. Aims Objectives: The present study was done to estimate (homeostatic model assessment - HOMA-IR) functional capacity (HOMA-B%) among newly detected diabetics correlation these with anthropometric, glucose, lipid parameters. Materials Methods: This an observational cross-sectional conducted 100 diagnosed Detailed anthropometric examination were carried out. Venous blood samples drawn fasting plasma c-peptide, level, hemoglobin A1C (HbA1C), profile, postprandial glucose. HOMA-IR HOMA-B% calculated using HOMA calculator correlations between the variables. Results: mean age population 45.55±11.64 years 58% participants male. 2.55±1.75 40.67±23.55%, respectively. positively correlated abdominal circumference, triglyceride HDLc ratio, negatively HDLc. There statistically significant negative glucose(r=−0.48, P<0.001), hr post prandial glucose (r=−0.37, P<0.001 HbA1C (r=−0.24, P=0.01). Conclusion: found more reduced compared sensitivity new T2D mellitus this kind needs be selecting appropriate anti-diabetic drugs particular patient.